Jan 11, 2013 09:32
11 yrs ago
English term

Сardiac dose

English to Russian Medical Medical (general)
chronic dosing of timolol eye drops may result in doses received by nursing infants about 1/160 of the cardiac dose and 1/80 if both eyes are treated.

спасибо!

Proposed translations

+1
6 mins

Доза, оказывающая кардиотоксическое действие

Propranolol, timolol and sotalol were compared regarding their cardiotoxic properties in isolated, perfused and catecholamine depleted rat hearts. Catecholamine depletion was performed in order to exclude interference of the drugs with beta-adrenergic receptors. The results demonstrate that both in spontaneously beating and atrial- stimulated hearts propranolol (3 - 30 micrograms/ml) and timolol (30 - 300 micrograms/ml) induced a dose dependent decrease in myocardial contractility, stimulus formation and stimulus conduction.

http://www.ncbi.nlm.nih.gov/pubmed/6502785

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Note added at 8 mins (2013-01-11 09:40:48 GMT)
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см. также
http://www.drugcite.com/indi/?q=TIMOLOL MALEATE&s=&a=&i=CARD...
Peer comment(s):

agree e-solutions (X)
1 day 14 hrs
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1 day 13 hrs

доза, оказывающая воздействие на работу сердца

Очевидно, в определенных дозах препарат обладает побочным действием на сердце. Приведенная в качестве контекста фраза должна убедить, что применяемые дозы препарата (даже при закапывании в оба глаза) значительно ниже таковых, которые изменяют деятельность сердца ребенка.
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