Cátia Santana Nov 13, 2018:

@philgoddard This way you wrote the sentence it becomes clearer.

philgoddard Nov 13, 2018:

I wonder if they mean "Benefit was also observed in the metastatic setting, regardless of lines of prior therapy." If so, that would support Catia's suggestion.

Cátia Santana Nov 13, 2018:

In this case, the term means the context where the therapy occurs.
See the meanings of the term here: https://www.thefreedictionary.com/setting

Chinh Chu (asker) Nov 13, 2018:

Other usages of "setting" The median age of patients enrolled in this study was XX years (range XX-XX), XX.X% of patients had received chemotherapy and XX.X% had received antihormonal therapy in the adjuvant setting prior to their diagnosis of advanced breast cancer while XX.X% of patients had received no prior systemic therapy in the adjuvant setting.