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This question was closed without grading. Reason: Other
Mar 18, 2022 10:12
2 yrs ago
38 viewers *
Spanish term

SEM

Spanish to English Medical Medical (general) Urology/Oncology
The following appears in a the patient history for a patient with carcinoma of the bladder:
RTU vejiga y prodtata (11/2020): carcinoma urotelial de vejiga T1AG + CIS.
RTU vejiga (12/2020): SEM. Instilaciones con BCG según protocolo ENCORE (inducción completa).
RTU vejiga (4/2021): Ta alto grado. Inicia tratamiento BCG + novolumab/placebo + [illegible] ensayo clínico [redacted].
Can anyone suggest what "SEM" is intended to indicate in this context? Thanks.
Proposed translations (English)
3 scanning electron microscopy
References
ENCORE study

Discussion

Lirka Mar 19, 2022:
I agree that it is probably "WEEKLY" It makes sense in the clinical context of BCG instillations.
Douglas Davies (asker) Mar 18, 2022:
Thanks for your suggestions Abe. From my research, I think the ENCORE trial may be more about the anesthesia. You may be right that it is intended to be an abbreviation of "semanal" and should be "Sem." I certainly take your point about the expense. I've found the name of the site from a similar report: Clinica Universitario Navarra.
abe(L)solano Mar 18, 2022:
Maybe the clue is on the ENCORE trial, apparently the patient was participating on it, it says so a couple of times. But I can't find the abstract or more info on ENCORE.
abe(L)solano Mar 18, 2022:
Electron Microscopy is done only in research, not on an every-day basis and for many patients. This report looks quite ordinary, do you have an idea of how costly electron microscopy is and the time it take to prepare the samples? Besides SEM is for detect changes at a very fine/small level. I don't think they want to describe subcellular changes when administering the BCG therapy! Nowadays we have several other techniques (less costly and time-consuming) to see cellular/tissue changes (hybridization, molecular tagging, gene/protein expression, etc.). Finally, SEM can be a lot of things and this is in Spanish. I don't se the point in writing 'SEM' when in Spanish is Microscopía electrónica (ME). Cheers
Douglas Davies (asker) Mar 18, 2022:
"Semanal" is an option, although it seems strange that it is in capitals in that case.
Douglas Davies (asker) Mar 18, 2022:
The SEM appears to be a separate procedure from the BCG instillation. Scanning Electron Microscopy currently seems to me to be the most likely candidate.
abe(L)solano Mar 18, 2022:
Well, after checking some protocols yes RTU=reseccion transuretral (this is a man 'cause it's indicated "prostate". But definitively not EM (electron microscopy). BCG instillations are administered as immunotherapy in the urinary tract, not in fixed & prepared tissue slices!!!
Nestor Jerez Mar 18, 2022:
RTU = Resección Trans-Uterina..?
philgoddard Mar 18, 2022:
Thanks So transurethral resection. In that case I don't see how Liz's answer fits the context. Could it be "sin éxito" something? Just guessing.
Douglas Davies (asker) Mar 18, 2022:
Hi Phil. RTU = TUR (common term). I think Liz's suggestion is the probable answer.
philgoddard Mar 18, 2022:
What's RTU? That might help.

Proposed translations

1 hr

scanning electron microscopy


bladder tumor turbt: Topics by Science.gov
https://www.science.gov › topicpages › bladder+tumor+tu...
The transurethral resection of bladder tumor (TURBT) remains the most widely used ... Immunogold scanning electron microscopy (SEM) in the backscattered ...

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Note added at 7 hrs (2022-03-18 17:28:50 GMT)
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Scanning electron microscopic findings in interstitial cystitis
https://pubmed.ncbi.nlm.nih.gov › ...
by CR Anderström · 1989 · Cited by 66 — Scanning electron microscopy (SEM) was performed on transurethral resection biopsies from 13 patients with classic interstitial

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Note added at 7 hrs (2022-03-18 17:31:11 GMT)
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Treatment for non-muscle-invasive bladder cancer
https://www.cancervic.org.au › types-of-cancer › treatm...
BCG is given once a week for six weeks, starting 2–4 weeks after TURBT surgery. It is put directly into the bladder through a catheter. This is usually done as ...

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Note added at 7 hrs (2022-03-18 17:36:43 GMT)
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only other finding was


semanales

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Note added at 7 hrs (2022-03-18 17:38:06 GMT)
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Inmunoterapia con el bacilo de Calmette-Guérin en ... - Elsevier
https://www.elsevier.es › es-revista-re...
· Translate this page
Al momento de la instilación intravesical, el BCG se fija al urotelio a ... y el Southwest Oncology Group (SWOG): una instilación semanal de inducción por ...

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Note added at 7 hrs (2022-03-18 17:38:19 GMT)
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so

weekly

could be more likely
Note from asker:
Many thanks Liz. I was leaning towards that, but unsure.
Hi Liz. I still think this could be correct, as they are completely separate procedures (separated by a full stop). "Semanal" was another option I considered, but why is it is capitalized in that case?
Hi Liz. Adter thinking nmore about it, I think that "Semana" was probably the intended meaning, even though it was in caps.
Peer comment(s):
agree slothm
1 hr
disagree abe(L)solano : Sorry Liz, not this. The acronym/abbrev.is in Spanish not English and you don't perform bcg instillations in a sliced & fixed tissue!/Yes, maybe "semanal" but not sure
5 hrs
BCG is given once a week for six weeks, starting 2–4 weeks after TURBT surgery. It is put directly into the bladder through a catheter. /Perhaps "semanales".
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Reference comments

21 hrs
Reference:

ENCORE study

https://britishjournalofcancerresearch.com/wp-content/upload...

"There are 15 instillations during the clinical trial, 6 instillations on induction phase (*once per week* during first six weeks after inclusion), and 3 instillations (*one per week*) on month three, another three on moth six and last three on month twelve, during maintenance phase."

"All patients must have undergone a second transurethral bladder resection as re-staging procedure (re-TUR)."
Peer comments on this reference comment:
agree abe(L)solano
16 mins
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