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rationnel pharmacocinétique-pharmacodynamique

English translation: pharmacokinetic/pharmacodynamic rationale

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
French term or phrase:rationnel pharmacocinétique-pharmacodynamique
English translation:pharmacokinetic/pharmacodynamic rationale
Entered by: Drmanu49

17:13 Sep 8, 2012
French to English translations [PRO]
Medical - Medical: Pharmaceuticals
French term or phrase: rationnel pharmacocinétique-pharmacodynamique
Compte tendu d'un rationnel pharmacocinétique-pharmacodynamique face à la situation épidémiologique actuelle, des augmentations de doses par rapport aux posologies actuellement mentionnées dans les AMM concernées doivent être requises.

In view of the pharmacokinetic-pharmacodynamic rationale in the current epidemiological context, increases in doses versus the current MA dosages are required.

Any ideas about the "rationnel" ? What does it refer to and how do we say it in English?

Context: Evaluation of a fixed combination of antibiotics.

Thanks in advance.
CMarc
France
Local time: 09:11
pharmacokinetic/pharmacodynamic rationale
Explanation:
jac.oxfordjournals.org/content/58/5/987.full.pdf - Traduire cette page
de JF Roos - 2006 - Cité 34 fois - Autres articles
Pharmacokinetic-pharmacodynamic rationale for cefepime dosing regimens in intensive care units. Juliana F. Roos1*, Jurgen Bulitta2, Jeffrey Lipman3 and Carl ...
Gatifloxacin and the elderly - Journal of Antimicrobial Chemotherapy
jac.oxfordjournals.org/content/52/3/435.full.pdf - Traduire cette page
de PG Ambrose - 2003 - Cité 53 fois - Autres articles
Journal of Antimicrobial Chemotherapy (2003) 52, 435–440. DOI: 10.1093/jac/dkg370. Advance Access publication 13 August 2003. 435 ...
Single-dose azithromycin for acute otitis media: A pharmacokinetic ...
www.currenttherapeuticres.com/article/.../abstract - Traduire cette page
de CD Rothermel - 2003 - Cité 22 fois - Autres articles
Single-dose azithromycin for acute otitis media: A pharmacokinetic/pharmacodynamic rationale. Constance D. Rothermel, PhD ...

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Note added at 19 minutes (2012-09-08 17:32:37 GMT)
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dictionary.reference.com/browse/rationale - Traduire cette page
the fundamental reason or reasons serving to account for something. 2. a statement of reasons. 3. a reasoned exposition of principles. Relevant Questions ...
Selected response from:

Drmanu49
France
Local time: 09:11
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +3pharmacokinetic/pharmacodynamic rationale
Drmanu49
4 +3pharmacokinetic-pharmacodynamic considerations
SJLD
4pharmacokinetic-pharmacodynamic justification
sktrans
3pharmacokinetic-pharmacodynamic thinking
DLyons
3Pharmacokinetic and pharmacodynamic reasoning
liz askew
Summary of reference entries provided
rationale
Daryo

  

Answers


4 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
pharmacokinetic-pharmacodynamic thinking


Explanation:
Point of view

DLyons
Ireland
Local time: 08:11
Specializes in field
Native speaker of: English
PRO pts in category: 34
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18 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +3
pharmacokinetic/pharmacodynamic rationale


Explanation:
jac.oxfordjournals.org/content/58/5/987.full.pdf - Traduire cette page
de JF Roos - 2006 - Cité 34 fois - Autres articles
Pharmacokinetic-pharmacodynamic rationale for cefepime dosing regimens in intensive care units. Juliana F. Roos1*, Jurgen Bulitta2, Jeffrey Lipman3 and Carl ...
Gatifloxacin and the elderly - Journal of Antimicrobial Chemotherapy
jac.oxfordjournals.org/content/52/3/435.full.pdf - Traduire cette page
de PG Ambrose - 2003 - Cité 53 fois - Autres articles
Journal of Antimicrobial Chemotherapy (2003) 52, 435–440. DOI: 10.1093/jac/dkg370. Advance Access publication 13 August 2003. 435 ...
Single-dose azithromycin for acute otitis media: A pharmacokinetic ...
www.currenttherapeuticres.com/article/.../abstract - Traduire cette page
de CD Rothermel - 2003 - Cité 22 fois - Autres articles
Single-dose azithromycin for acute otitis media: A pharmacokinetic/pharmacodynamic rationale. Constance D. Rothermel, PhD ...

--------------------------------------------------
Note added at 19 minutes (2012-09-08 17:32:37 GMT)
--------------------------------------------------

dictionary.reference.com/browse/rationale - Traduire cette page
the fundamental reason or reasons serving to account for something. 2. a statement of reasons. 3. a reasoned exposition of principles. Relevant Questions ...

Drmanu49
France
Local time: 09:11
Specializes in field
Native speaker of: Native in EnglishEnglish, Native in FrenchFrench
PRO pts in category: 1131

Peer comments on this answer (and responses from the answerer)
agree  Bashiqa: See nothing wrong with keeping rationale.
43 mins
  -> Thank you. It is commonly usd indeed.
agree  Daryo: the most accurate variant
2 hrs
  -> Yes and evidently not a literal translation!
agree  philgoddard: Though I could only find "logique" and "raisonnement" for "rationale". "Un rationnel" usually seems to mean "a rational number".
11 hrs
  -> yes, thank you Phil.
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26 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
Pharmacokinetic and pharmacodynamic reasoning


Explanation:
Quantitative Pharmacology: An Introduction to ... - Amazon.co.uk
www.amazon.co.uk › ... › Pharmaceutical Technology
Tennessee and University of Manchester. He has published extensively in the field of pharmacokinetic-pharmacodynamic modeling and reasoning, and has run ...

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Note added at 30 mins (2012-09-08 17:43:10 GMT)
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rationnel :: Lexipedia - Where words have meaning
www.lexipedia.com/french/rationnel
rationnel. adj. capable of being expressed as a quotient of integers; "rational numbers". rationnel. adj. consistent with or based on or using reason; "rational ...
French Translation of rational | Collins English French Dictionary
www.collinsdictionary.com/dictionary/english-french/rationa...
[decision, explanation, argument] rationnel(le); [solution] rationnel(le); [thought, thinking, mind, reasoning] rationnel(le). (psychology, psychiatry(= of sound mind) ...

liz askew
United Kingdom
Local time: 08:11
Works in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 465
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54 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +3
pharmacokinetic-pharmacodynamic considerations


Explanation:
In view of the pharmacokinetic-pharmacodynamic considerations demanded by the current epidemiological situation

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Note added at 1 hr (2012-09-08 18:53:33 GMT)
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or strategies - even better

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Note added at 1 hr (2012-09-08 18:57:25 GMT)
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increases in doses versus the current MA dosages are required

I don't think so - there is no "versus"

des augmentations de doses par rapport aux posologies actuellement mentionnées dans les AMM concernées doivent être requises

increases in the dosages that have currently received marketing authorisation must be requested/demanded



SJLD
Local time: 09:11
Specializes in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 258

Peer comments on this answer (and responses from the answerer)
agree  Nikki Scott-Despaigne: Practical solution. The difficulty here is how to render "rationnel".
1 hr
  -> thanks Nikki - the challenge of texts like this is to understand what the author really wants to say and transform it into palatable English - IOW best to avoid literal translations
agree  Helen Genevier
21 hrs
  -> thanks Helen :-)
agree  Joanne Archambault: I'd go with strategies here
1 day 19 hrs
  -> yes, that's what I prefer - thanks Joanne :-)
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1 hr   confidence: Answerer confidence 4/5Answerer confidence 4/5
pharmacokinetic-pharmacodynamic justification


Explanation:
Pharmacokinetic perspectives on megadoses of ascorbic acid.www.ajcn.org/content/66/5/1165You +1'd this publicly. Undo
by J Blanchard - 1997 - Cited by 53 - Related articles
As a consequence of this ceiling effect, there is no pharmacokinetic justification for the use of megadoses of ascorbic acid. « Previous | Next Article » Table of ...
[PDF]


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Note added at 1 hr (2012-09-08 19:07:27 GMT)
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[PDF]
Guideline on Strategies to Identify and Mitigate Risks for First-In ...www.ema.europa.eu/pdfs/human/swp/2836707enfin.pdfSimilar
You +1'd this publicly. Undo
File Format: PDF/Adobe Acrobat - Quick View
by ENDOF CONSULTATION - 2007 - Related articles
pharmacokinetic and pharmacodynamic parameters and the trial objectives such as justifying progression to the next cohort. While larger cohorts are likely to ...
[PDF]
Introduction to Pharmacokinetics and Pharmacodynamicswww.ashp.org/DocLibrary/Bookstore/P2418-Chapter1.aspxYou +1'd this publicly. Undo
File Format: PDF/Adobe Acrobat - Quick View
Lesson 1: Introduction to Pharmacokinetics and Pharmacodynamics. 3 regulation results in ...... drug concentrations would be a good justification for therapeutic ...
Dr Jürgen B Bulittawww.pharm.monash.edu.au › Faculty › StaffCached
You +1'd this publicly. Undo
Nov 16, 2011 – Application of Pharmacokinetic-Pharmacodynamic Modeling and Justification of a Novel Fusidic Acid Dosing Regimen: Raising Lazarus from ...


sktrans
Local time: 03:11
Specializes in field
Native speaker of: Native in ArabicArabic, Native in FrenchFrench
PRO pts in category: 119
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Reference comments


2 hrs
Reference: rationale

Reference information:
rationale

ra·tion·ale
 
noun
1.
the fundamental reason or reasons serving to account for something.
2.
a statement of reasons.
3.
a reasoned exposition of principles.

Origin:
1650–60; < Latin: neuter of ratiōnālis rational

Synonyms
1. logic, basis, grounds.
[http://dictionary.reference.com/browse/rationale]

Daryo
United Kingdom
Native speaker of: Native in SerbianSerbian, Native in FrenchFrench
PRO pts in category: 16
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