keyboard design
Spanish translation: diseño tipo Keyboard (bayesiano)
| 12:15 Nov 4, 2022 |
| English to Spanish translations [PRO] Medical - Medical: Pharmaceuticals / Clinical trials | |||||||
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|  Selected response from: abe(L)solano France | ||||||
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| Summary of answers provided | ||||
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| 4 | diseño tipo Keyboard (bayesiano) |
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| 3 | un diseño clave y central |
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| Summary of reference entries provided | |||
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| Bayesian Designs for Early Phase Clinical Trials with Novel Target Agents |
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| diseño experimental bayesiano? |
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| Discussion entries: 2 | |
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Answers
1 day 3 hrs confidence: 
un diseño clave y central Explanation: Se explica que los participantes jurídicos se matruculan entre grupos de asociados y según los niveles y las cuantías de las dosis de la droga. Empiezan con unas dosis pequeñas antes de progresar a unas dosis medianas y luego otras dosis más altas de la droga. -------------------------------------------------- Note added at 1 day 4 hrs (2022-11-05 16:15:41 GMT) -------------------------------------------------- EN: It's a key central design of clinical drug experimentation. 'Eligible participants are enrolled according to associated groups depending on the levels or the amounts of the dose of the drug involved in the clinical trial. The doses begin with a small amount which then increases to a larger dose before progressing on to an even larger drug dose as part of the same trial.' -------------------------------------------------- Note added at 1 day 4 hrs (2022-11-05 16:28:45 GMT) -------------------------------------------------- (I don't like to imagine the effects of such a trial with increasing drug doses.) |
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2 days 20 hrs confidence:
diseño tipo Keyboard (bayesiano) Explanation: Hola, David. Vale, te lo dejo aquí como respuesta formal. "Keyboard" debería ir en itálicas, pero la casilla de la respuesta no deja. Ver refs. Saludos cordiales, Abe. http://publicaciones.portalfarma.com/pam/366/files/assets/co... Para ello, se llevó a cabo en un marco estadístico de tipo bayesiano, un meta-análisis de tratamientos múltiples (que utiliza ambas comparaciones directas e indirectas) de ensayos controlados aleatorios, comparando 15 fármacos antipsicóticos y placebo en el tratamiento agudo de la esquizofrenia... https://www.clinicaltrialsregister.eu/ctr-search/trial/2012-... Estudio de búsqueda de pauta posológica, controlado con placebo, doble ciego, con grupos paralelos y con diseño bayesiano> de aleatorización adaptativa para evaluar la seguridad, la tolerabilidad y la eficacia de BAN2401 en sujetos con enfermedad de Alzheimer incipiente. |
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Reference comments
1 hr peer agreement (net): +2 |
| Reference: Bayesian Designs for Early Phase Clinical Trials with Novel Target Agents Reference information: Por si fuese útil https://www.researchgate.net/publication/328190240_Bayesian_... Keyboard: A Novel Bayesian Toxicity Probability Interval Design for Phase I Clinical Trials https://www.researchgate.net/publication/317186460_Keyboard_... -------------------------------------------------- Note added at 1 hora (2022-11-04 13:35:07 GMT) -------------------------------------------------- En Pubmed (segundo paper): https://pubmed.ncbi.nlm.nih.gov/28546227/ "We propose the keyboard design, an intuitive Bayesian design that conducts dose escalation and de-escalation based on whether the strongest key, defined as the dosing interval that most likely contains the current dose, is below or above the target dosing interval." Yo sinceramente lo dejaría como "diseño tipo keyboard". Es algo bastante específico, y aún no he visto muchos estudios que lo usen. -------------------------------------------------- Note added at 2 horas (2022-11-04 14:43:17 GMT) -------------------------------------------------- Sí, yo no usaría "diseño de teclado" para nada!! |
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