Oct 8, 2011 08:04
12 yrs ago
English term
Germany
medical translator, editor
Native in: Russian 
Works in: English to Russian, Russian to English
MI numbers
English to Russian
Other
Medical: Pharmaceuticals
List of excepients: Only inert ingredients corresponding to the MI numbers used for the formulations marketed by the particular subsidiary should be listed
Proposed translations
(Russian)
| 4 | номер в каталоге Мерк |
Aleksey Kornilov
|
| 4 | ограничения по массовой интенсивности (MI) |
Igor_2006
|
| 2 | концентрация |
Vaddy Peters
|
Proposed translations
39 mins
Aleksey Kornilov
Russian Federation
Russian Federation
Native in Russian
Works in field
Russian Federation
Related KudoZ points
:
40
Selected
номер в каталоге Мерк
Применяется наряду с номером CAS.
4 KudoZ points awarded for this answer.
36 mins
концентрация
www.pharmamanufactu... -
B.C.: The two most common green metrics used by drug manufacturers are mass intensity (MI), sometimes called process mass intensity, and E-Factor (E).
B.C.: The two most common green metrics used by drug manufacturers are mass intensity (MI), sometimes called process mass intensity, and E-Factor (E).
43 mins
ограничения по массовой интенсивности (MI)
Список вспомогательных веществ: Только инертные ингредиенты, соответствующие ограничениям по массовой интенсивности, ...
Речь идет об экологических ограничениях по воздействию производства (фармакологических ингредиентов) на окружающую среду. Массовая интенсивность - одна из мер такого воздействия. Вот на английском:
PhM: First, a general question: How extensive and reliable are the so-called green metrics that the average drug manufacturer uses? Do manufacturers really have a good handle on the environmental impact of their processes and operations?
B.C.: The two most common green metrics used by drug manufacturers are mass intensity (MI), sometimes called process mass intensity, and E-Factor (E). Both relate the weight (mass) of the API produced to the weight (mass) of all solvents, reagents, process aids, and, in the case of mass intensity, process water used to manufacture the API. Neither metric tracks solvent/water/cleaning agents used to clean the equipment between runs and this can be a very large number.
E-Factor has been around longer than mass intensity and they are related by E = MI-1—E-factor measures waste generated while MI measured total resource utilization. Typical E-factors or MI’s are > 100 with the industry best E/MI around 10. That means the typical API process consumes > 100 kg of materials to produce 1 kg of API. There is clearly room for improvement.
The ACS Green Chemistry Institute Pharmaceutical Roundtable members have benchmarked their MI numbers for API processes in R&D twice.
http://www.pharmamanufacturing.com/articles/2011/059.html
Ниже ссылка на русском из Журнала российского хим. общества. Процитировать не могу (там что-то с кодировкой), посмотрите слева вверху на 11 странице:
http://www.chem.msu.su/rus/jvho/2004-6/3.pdf
Речь идет об экологических ограничениях по воздействию производства (фармакологических ингредиентов) на окружающую среду. Массовая интенсивность - одна из мер такого воздействия. Вот на английском:
PhM: First, a general question: How extensive and reliable are the so-called green metrics that the average drug manufacturer uses? Do manufacturers really have a good handle on the environmental impact of their processes and operations?
B.C.: The two most common green metrics used by drug manufacturers are mass intensity (MI), sometimes called process mass intensity, and E-Factor (E). Both relate the weight (mass) of the API produced to the weight (mass) of all solvents, reagents, process aids, and, in the case of mass intensity, process water used to manufacture the API. Neither metric tracks solvent/water/cleaning agents used to clean the equipment between runs and this can be a very large number.
E-Factor has been around longer than mass intensity and they are related by E = MI-1—E-factor measures waste generated while MI measured total resource utilization. Typical E-factors or MI’s are > 100 with the industry best E/MI around 10. That means the typical API process consumes > 100 kg of materials to produce 1 kg of API. There is clearly room for improvement.
The ACS Green Chemistry Institute Pharmaceutical Roundtable members have benchmarked their MI numbers for API processes in R&D twice.
http://www.pharmamanufacturing.com/articles/2011/059.html
Ниже ссылка на русском из Журнала российского хим. общества. Процитировать не могу (там что-то с кодировкой), посмотрите слева вверху на 11 странице:
http://www.chem.msu.su/rus/jvho/2004-6/3.pdf
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