La dermatitis atópica (DA) es una enfermedad inflamatoria crónica multifactorial y de evolución impredecible, en la cual interaccionan una base genética compleja (diátesis atópica) y múltiples factores desencadenantes. La DA del adulto cursa con prurito intenso, xerosis, placas de eccema liquenificadas y excoriaciones, y actualmente no se dispone de ningún tratamiento curativo. Recientemente se ha publicado la elevada eficacia de la inmunoterapia específica (ITE) con alergenos de los ácaros del polvo doméstico (APD) en pacientes adultos con DA grave sensibilizados a estos alergenos.

http://www.actasdermo.org/es/inmunoterapia-especifica-con-al...

To this end, identification, expression,and purification of recombinant allergens provide reagentquantities of protein for future use in serologic testing, to identify individuals at risk for hypersensitivity to bed bugbites that may ultimately lead to the development ofspecific immunotherapy for C. lectularius antigens for patients at risk.

Bullous Allergic Hypersensitivity to Bed Bug Bites Mediated by IgE against Salivary Nitrophorin (PDF Download Available). Available from: https://www.researchgate.net/publication/7355668_Bullous_All... [accessed Feb 04 2018].

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Note added at 26 mins (2018-02-04 14:22:39 GMT)
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Objective
To analyze the 3-year effect of sublingual allergen-specific immunotherapy (SLIT) to house dust mites in elderly patients with allergic rhinitis.

http://www.annallergy.org/article/S1081-1206(17)30389-7/pdf

Introduction
Together with allergen avoidance, allergen-specific immunotherapy (SIT) is the only available treatment able to affect the natural course of allergy. It is validated for IgE-mediated sting allergies and respiratory allergies, i.e. allergic rhinitis and asthma. Since the first use of SIT in the early 20th century,1 a large amount of clinical trials have been conducted and published, most of them being placebo-controlled. These trials made SIT become an evidence-based treatment and brought insights into SIT mechanisms, efficacy and safety. These insights served to figure out indications and contra-indications of SIT, and the necessary rules to be applied to improve the benefit/risk ratio of this treatment. These rules were relayed in international guidelines. More recently, allergen extracts were successfully proposed as sublingual tablets in allergic rhinitis.

https://www.sciencedirect.com/science/article/pii/S095461110...

Allergen immunotherapy, also known as desensitization or hypo-sensitization, is a medical treatment for some types of allergies. It is useful for environmental allergies, allergies to insect bites, and asthma. Its benefit for food allergies is unclear and thus not recommended. Immunotherapy involves exposing people to larger and larger amounts of allergen in an attempt to change the immune system's response.

Meta-analyses have found that injections of allergens under the skin are effective in the treatment in allergic rhinitis in children and in asthma. The benefits may last for years after treatment is stopped. It is generally safe and effective for allergic rhinitis, allergic conjunctivitis, allergic forms of asthma, and stinging insects. The evidence also supports the use of sublingual immunotherapy against rhinitis and asthma, but it is less strong. In this form the allergen is given under the tongue and people often prefer it to injections. Immunotherapy is not recommended as a stand-alone treatment for asthma.

https://en.wikipedia.org/wiki/Allergen_immunotherapy

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Note added at 33 mins (2018-02-04 14:29:36 GMT)
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Las indicaciones estrictas para la inmunoterapia alergeno-específica (ITE)
son: la presencia de IgE-alergeno-específica in vivo y/o in vitro, síntomas con
la exposición frente al alergeno, imposibilidad de controlar la presencia de
alergeno en el medio ambiente, sintomatología persistente con farmacoterapia
de sostén (más de 6 meses). La ITE es la administración de cantidades
incrementadas de extractos alergénicos (EA) en P/V, microgramos/mL, UNP/
mL, UA/mL, BAU/mL, UB/mL, en pacientes atópicos con rinitis y/o asma
extrínseco alérgicos, o anafilaxia a piquetes de insectos, mediado por anticuerpos IgE.

http://www.medigraphic.com/pdfs/bioquimia/bq-2009/bqm091q.pd...