English to Russian Medical Medical: Pharmaceuticals оценка связывания лекарственного вещества с белками плазмы методом диализа

Plasma blinding experiments confirmed that the binding of vinpocetine is decreased in patients with liver impairment as the **average dialysation cell ratio** was 115 in healthy subjects and 101 in the liver patients.

Regarding the pharmacokinetics, in both groups vinpocetine plasma concentrations decay bi-exponentially and the final curves suggested that vinpocetine is eliminated in patients with liver impairment at a significantly slower rate than in healthy volunteers.


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